Overview
GS-441524 is a potent nucleoside analog antiviral that targets the mutated feline coronavirus causing FIP, a once-fatal disease in cats. Available in convenient oral (tablets or suspension) and subcutaneous injection forms, it offers over 85-92% success rates in achieving full remission with a standard 12-week course. This life-saving therapy is especially vital for wet, dry, ocular, or neurological FIP cases, providing hope where none existed before.
Key Functionalities
- Inhibits viral replication by mimicking RNA building blocks, halting FIP progression.
- Rapidly resolves symptoms like fever, effusion, weight loss, and neurological issues.
- Oral form ideal for long-term ease; injections ensure precise delivery for severe cases.
- High barrier to resistance with proper dosing; effective for kittens and adults alike.
Usage and Dosage
Administer under veterinary guidance only. Start with injections for critically ill cats (e.g., vomiting), transitioning to oral as symptoms improve.
- Standard (non-neurological FIP): 4-6 mg/kg subcutaneous (SC) once daily or 10-15 mg/kg oral once daily.
- Ocular/Neurological FIP: 8-10 mg/kg SC daily or 20 mg/kg oral (split 10 mg/kg twice daily).
- Duration: 84 days (12 weeks); monitor bloodwork biweekly. Store at room temperature; mix oral suspension with food if needed. Missed dose? Skip and resume schedule-never double up.
Potential Side Effects
GS-441524 is remarkably well-tolerated with no serious systemic risks. Common:
- Injections: Mild pain, swelling, or irritation at site (treat with topical steroids; rare skin reactions).
- Oral: Occasional mild liver enzyme elevation or lymphocytosis (non-progressive).
- Rare: Temporary kidney changes or bladder stones (ensure hydration; monitor urinary symptoms). Contact your vet for any unusual signs like lethargy or appetite loss.